A Practical Guide to Cancer Systems Biology

Authors : Hsueh-Fen Juan (National Taiwan University, Taiwan), Hsuan-Cheng Huang (National Yang-Ming University, Taiwan)

Publisher : World Scientific

ISBN : 978-981-3229-14-3

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Systems biology combines computational and experimental approaches to analyze complex biological systems and focuses on understanding functional activities from a systems-wide perspective. It provides an iterative process of experimental measurements, data analysis, and computational simulation to model biological behavior. This book provides explained protocols for high-throughput experiments and computational analysis procedures central to cancer systems biology research and education. Readers will learn how to generate and analyze high-throughput data, therapeutic target protein structure modeling and docking simulation for drug discovery. This is the first practical guide for students and scientists who wish to become systems biologists or utilize the approach for cancer research.
Hsueh-Fen Juan received her BS and MS degree in Botany and PhD in Biochemical Sciences from National Taiwan University (NTU) in 1999. She worked as a research scientist in the Japan International Research Center for Agricultural Sciences (Tsukuba, Japan) during 2000–2001 and a postdoctoral research fellow in the Institute of Biological Chemistry, Academia Sinica (Taipei, Taiwan) during 2001–2002. She started her academic career in the Department of Chemical Engineering, National Taipei University of Technology as an assistant professor and in the Department of Computer Science and Information Engineering at NTU as an adjunct assistant professor in 2002. She moved to NTU in 2004 as an assistant professor in the Department of Life Science and the Institute of Molecular and Cellular Biology. She was promoted to be an associate professor in 2006 and full professor in 2009 in the Department of Life Science, Institute of Molecular and Cellular Biology and Graduate Institute of Biomedical Electronics and Bioinformatics, NTU. Dr Juan is currently working on systems biology by integrating genomics, transcriptomics, proteomics and bioinformatics for molecular signaling as well as biomarker and drug discovery.

Prof. Juan has developed a number of novel methods to advance systems-biology research and applied such approach for drug discovery and elucidating molecular mechanism of drug responses in cancer cells. She has published more than 100 journal papers and is now the editor of several journals including Scientific Reports (Nature Publishing Group). To promote systems biology field, she has organized several international systems biology symposiums. She is one of the founders of Center for Systems Biology and Bioinformatics (NTU), and currently the Council Member of three societies, the Taiwan Bioinformatics and Systems Biology Society, Taiwan Proteomics Society, and Taiwan Society of Evolution and Computational Biology and Supervisor of Taiwan Society for Biochemistry and Molecular Biology. Since Dr Juan made significant contributions through systems biology approach to development of methodology and cancer therapy; she received the awards "Taiwan's Ten Outstanding Young Persons", FY2011 JSPS Invitation Fellowship Program for Research in Japan, K T Li Breakthrough Award by Institute of Information and Computing Machinery, National Science Council (NSC)/Ministration of Science and Technology (MOST) Award for Special Talents of the Colleges and USA Emerging Information and Technology Association (EITA) Service Award. Additionally, she has been invited to give more than 150 talks worldwide and leads her team members to obtain more than 70 research awards.

Hsuan-Cheng Huang received his BA, MA, and PhD degrees in physics from National Taiwan University in 1992, 1994 and 1998, respectively. He was engaged in experimental high-energy physics research at Taiwan and at High Energy Accelerator Research Organization, Japan, and awarded NSC Distinguished Postdoctoral Fellowship in 2003. Encouraged by the emerging of systems biology, Dr Huang joined National Yang-Ming University in 2004 and is currently a Professor and the Director of the Institute of Biomedical Informatics, also affiliated with the Center for Systems and Synthetic Biology. In 2007, he received the NSC Wu Ta-You Memorial Award, an honor for excellent young investigators in Taiwan. Now he serves as an Editorial Board Member of Scientific Reports, an Associate Editor and Deputy Section Editor of BMC Systems Biology, and an Executive Board Member in Taiwan Society of Evolution and Computational Biology. His research interests include bioinformatics, computational and systems biology, and network biology. Currently, Dr Huang endeavors his research efforts to computational analysis and modeling of biological networks, and applies them to unravel molecular mechanisms of cancer cell response, non-coding RNA regulation, as well as other biological processes.
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