Reproducibility is the gold standard in science. In science, papers must describe methods that others can use to get or reproduce the same results. Reproducibility is crucial in chemistry and related fields. Irreproducibility can mean that the results are unsound, experimental methods described are flawed, or there is dishonesty in reporting results.

A recent Nature survey showed that more than 70% of the researchers failed when they tried to replicate. Additionally, more than 50% were unsuccessful in replicating results from other published studies. However, they still believed in the quality and rigor of the published work. According to this survey, chemistry topped the list of discipline in which most researchers were unable to replicate their own or other’s work. Organic Syntheses, for instance, rejected around 7.5% manuscripts due to irreproducibility between 2010 and 2016. It may be difficult to reproduce compounds in natural product chemistry but this situation is lot better in the fields of medicinal chemistry and drug discovery.